Gum infection could be linked to Alzheimer’s, study says
Jan 27, 2019, 01:33
Researchers at Shiley-Marcos Alzheimer's DiseaseResearch Center, part of the University of California San Diego School of Medicine, found that autopsies of patients diagnosed with AD when they were alive-and confirmed by autopsy-indicate several cognitive issues symptomatic of the condition are less noticeable in living Latino patients.
A treatment using the compound, called COR388, recently passed human safety studies in Alzheimer's disease patients and healthy adults and will move into the next step of clinical trials this year, Lynch said.
Bacteria involved in gum disease and other illnesses have been found after death in the brains of people who had Alzheimer's, but until now, it hasn't been clear whether these bacteria caused the disease or simply got in via brain damage caused by the condition.
It's possible that news of the possible link will lead to people spending more time on their dental health than they now do, though: One study found less than one third of Americans floss daily.
Disrupted sleep was also found to increase release of synuclein proteins which are a hallmark of Parkinson's disease; people with this disease also often have sleep problems.
'In research we've supported to uncover the key risk factors for Alzheimer's disease, gum disease hasn't emerged as a major cause for concern, ' Dr James Pickett, head of research at Alzheimer's Society, said.
Alzheimer's disease is infamous for its devastating impact on memory, bringing significant mental and emotional stress to patients and their families.
The study included research of both mice and humans.
The study authors say these results, plus additional testing in mice, provide "solid evidence" of a link between the two diseases and may offer a potential new way to treat Alzheimer's. They also studied the enzyme's effects in the brains of mice, and found that it caused the animals to develop signs of Alzheimer's.
"We have provided evidence showing that abnormal epigenetic regulation of glutamate receptor expression and function did contribute to cognitive decline in Alzheimer's disease", Yan concluded.
There is now no test doctors can use to conclusively determine whether someone will get Alzheimer's disease and there are a lot of unknowns about its cause.
In the paper, an global team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the role of a common bacterium, Porphyromonas gingivalis (Pg), in driving Alzheimer's disease pathology and demonstrate the potential for small molecule inhibitors to block the pathogen.
They also showed that when genetically modified mice who were predisposed to Alzheimer's were infected with P. gingivalis, the bacterium ended up in their brain and that this was associated with increased levels of amyloid protein. They hope to conduct a Phase 2 trial to further test out their drug soon.
People with Lewy body dementia and Huntington's disease tend to have high levels of the protein in the blood. The Alzheimer's Association has a campaign called "10 Ways to Love Your Brain" to help people lower their risk.
Of the many changes in the brain which precede the disease's symptoms, one change is also the accumulation of NfL in the blood before any symptoms begin, said Jucker. Co-founder Stephen Dominy is a psychiatrist who in the 1990s became intrigued by the idea that Alzheimer's could have an infectious cause.
Hendren and his partner reported the shooting on their police radios and took Alix to the hospital in their police department SUV. On the third shot, Hendren pulled the trigger while pointing the gun at Alix, and the gun discharged, the statement reads.
The 21-year-old produced her best run at a grand slam at the 2018 Australian Open and has since soared to astonishing new heights. The two-time Wimbledon victor will be no.2 in the world thanks to her runner-up trophy, something she never thought might happen.
It's even worse if you own a Microsoft Lumia or Lumia XL: 11 June 2019 will be the last date those devices are supported. Microsoft says support for Internet Explorer on Windows 7 devices will as well be discontinued on January 14, 2020.
The Holness administration has not said whether it will order Venezuela to recall its ambassador to Kingston. Several other countries have also declared they will recognise Mr Guaido as Venezuela's interim president.
Inside you'll find soil, yeast, fruit fly and silkworm eggs, as well as cotton, potato, tomato, and (flowering) thale cress seeds. Fred Watson, the Australian Astronomical Observatory's astronomer at large, described the development to the BBC as "good news" .
The "Abolish ICE" movement has gained currency in numerous NY social circles she now represents in the House and on social media. The president's choice of a primetime national address had been much maligned by many in the political establishment.
Speaking to Lauren Ingraham, he said networks should instead be praising Trump for the job he is doing as President. So any time during that period, they could have talked about it", he said. "I don't know if they made it up".
Rose, the world number one, carded his 68 on the La Quinta course, while Laired fired his 72 on the Nicklaus Tournament Course. On 17, I hit a nice tee shot in a good spot to kind of hook a sand wedge into that back right pin for me.
Patterson is expected to be charged with two counts of 1st degree intentional homicide and one count of kidnapping. Smart told investigators she was raped daily and threatened with death if she tried to escape.
The world No.4 trailed a set and 4-1 before rallying to beat the crafty 28th seed 5-7 6-4 6-1 in the third round on Saturday. Naomi Osaka fought her way into the quarter finals of the Australian Open by seeing off Anastasija Sevastova in three sets.
The move means Chicago has yet another opening on its defensive coaching staff, which is now led by new coordinator Chuck Pagano . Arik Armstead, who is set to enter his fifth season, had a solid season in the run game but did not offer much as a pass-rusher.
De Blasio estimated that the city would spend about $100 million a year once the program is fully operating, in about two years. Residents will be able to access the program via the city's website or calling the city of NY at 311.
Which stars suffered Oscars nomination snubs?
Spike Lee is finally getting some love at the Oscars , an honour Thor Diakow from Breakfast Television says is much deserved. However, it was a bit shocking-almost offensively so-to see Bradley Cooper missing from that list for A Star Is Born .
Some Netflix Subscribers Say They'll Leave Over New Pricing
The company also said that " You ", a new thriller TV series, was watched by more than 40 million members in its first four weeks. According to The Globe And Mail , the footage has turned up both in Netflix's Bird Box and their sci-fi show, Travelers .
DFAT denies Australian man killed in Nairobi terror attack
Police uncovered a "huge hole dug in one of the rooms where guns were stored", he said. "Let them allow us in", she said, weeping. Godec said the United States is working closely with Kenyan authorities following the extremist attack in Nairobi this week.
US Teen Captured in Roundup of ISIS Jihadi
By Tuesday evening, Erdogan was declining a meeting with the USA national security adviser who had arrived to the Turkish capital. Since then, on January 7th he tweeted that the USA will "leave at a proper pace while at the same time continuing to fight ISIS".